Depression affects almost 1 in 10 adults living in the United States.1 Up to 30% of individuals with depression may not respond to traditional antidepressant therapy; therefore, research into alternative treatments is important.2 Alternative or augmentation therapies have been studied to treat patients with refractory depression or patients who require response or remission quicker than that of currently available antidepressants.3 One class of medications that has been studied as an alternative therapy but remains controversial for the treatment of depression is the psychostimulants, including methylphenidate.4
Layout table for study information Study Type : Interventional (Clinical Trial) ActualEnrollment : 181 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: The Use of Methylphenidate to Improve Clinical Outcomes in Geriatric Depression: A Double-blind Placebo-Controlled Trial of Methylphenidate (Ritalin) Augmentation of Citalopram (Celexa) in Depressed Elderly Patients Study Start Date : February 2008 Actual Primary Completion Date : January 2013 Actual Study Completion Date : February 2013 Resource links provided by the National Library of Medicine MedlinePlus Genetics related topics: Depression Drug Information available for: Methylphenidate Methylphenidate hydrochloride Citalopram hydrobromide Citalopram Escitalopram Escitalopram oxalate U.S. FDA Resources Arms and Interventions Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Arm Intervention/treatment Active Comparator: 1 - Citalopram and placeboParticipants will take a combination of citalopram and placebo for 16 weeks Drug: CitalopramCitalopram dosage will be 20 to 60 mg a day prior to FDA warning limiting it to 20-40 mg in 2011. Participants will begin taking one 20-mg capsule once per day for 4 weeks, and this dosage may be increased or decreased depending on the participant's response to the medication or side-effect profile. Participants will continue on their assigned dosage of citalopram that will be titrated up after week 4 if clinical global impressions (CGI) scores were > 2 until treatment completion.Other Name: Celexa Drug: PlaceboPlacebo pills will be taken in combination with the active pills. Participants will initially take 1 capsule twice per day, which will be increased to a maximum of 16 capsules twice per day matching methylphenidate, and 1-3 capsules matching citalopram. After Visit 11, placebo dosage will be gradually reduced over 2 weeks until participants are no longer taking any capsules. Active Comparator: 2 - Methylphenidate and placeboParticipants will take a combination of methylphenidate and placebo for 16 weeks Drug: Methylphenidate (MPH)MPH dosage will be 5 to 40 mg a day. Participants will initially take 1 capsule (2.5 mg) twice per day, which will be increased to a maximum up to 8 x 2.5 mg capsules twice per day. After Visit 11, MPH dosage will be gradually reduced over 2 weeks until participants are no longer taking any capsules.Other Name: Ritalin Drug: PlaceboPlacebo pills will be taken in combination with the active pills. Participants will initially take 1 capsule twice per day, which will be increased to a maximum of 16 capsules twice per day matching methylphenidate, and 1-3 capsules matching citalopram. After Visit 11, placebo dosage will be gradually reduced over 2 weeks until participants are no longer taking any capsules. Active Comparator: 3 - Methylphenidate and CitalopramParticipants will take a combination of methylphenidate and citalopram for 16 weeks Drug: CitalopramCitalopram dosage will be 20 to 60 mg a day prior to FDA warning limiting it to 20-40 mg in 2011. Participants will begin taking one 20-mg capsule once per day for 4 weeks, and this dosage may be increased or decreased depending on the participant's response to the medication or side-effect profile. Participants will continue on their assigned dosage of citalopram that will be titrated up after week 4 if clinical global impressions (CGI) scores were > 2 until treatment completion.Other Name: Celexa Drug: Methylphenidate (MPH)MPH dosage will be 5 to 40 mg a day. Participants will initially take 1 capsule (2.5 mg) twice per day, which will be increased to a maximum up to 8 x 2.5 mg capsules twice per day. After Visit 11, MPH dosage will be gradually reduced over 2 weeks until participants are no longer taking any capsules.Other Name: Ritalin Outcome Measures Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Primary Outcome Measures : Hamilton Depression Rating Scale (HDRS) Maintained Scores at Week 16 [ Time Frame: Maintained response measured at Week 16 ]The Hamilton Depression Rating Scale (HDRS) is a 24-item depression scale and the total score is summed with a minimum score=0 and maximum score=76. There are no subscales and the higher values represent a worse outcome. Outcomes are measured and defined as follows: 1) Response will be defined as HDRS scores of 10 or less; 2) Sustained response will be defined as maintained response at week 16; 4) Remission will be defined as HDRS scores of 6 or less. Secondary Outcome Measures : Quality of Life Assessment [ Time Frame: Measured at Baseline and Week 16 ]The Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form (Q-LES-Q-SF) is a 16 item self-administered questionnaire that captures life satisfaction over the past week. Each question is rated on a 5 point scale from 1 (Very Poor) to 5 (Very Good). The total score is reported for items 1-14. The minimum raw score on the Q-LES-Q-SF is 14, and the maximum score is 70 with higher values representing a better outcome. Eligibility CriteriaGo to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Layout table for eligibility information Ages Eligible for Study: 60 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria:
ritalin dosage for adults depression
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Methods: PubMed (1946-December 2020) and Embase (1947-December 2020) were queried using the following search terms: geriatrics, aged, geriatric patient, or elderly and depressive disorder, depression, major depression or late-life depression, and MPH. Studies were included if they were a randomized-controlled trial or open-label trial that investigated use of MPH for treatment of depression in adults aged 60 years and older.
Ritalin, like other stimulants, often causes psychological symptoms during withdrawal. Since Ritalin primarily works by influencing dopamine in the brain, withdrawal symptoms will be related to reward, emotion, and energy levels. You may feel apathetic, depressed, anxious, irritable, and tired.You may also feel rebounding symptoms if you took the drug as a prescription to treat narcolepsy or ADHD. In that case, you might experience hypersomnia or difficulty concentrating. The severity of your symptoms will depend on the length of time you were dependent on the drug and the size of your normal dose. Symptoms are generally worse if you quit suddenly in \u201ccold turkey\u201d fashion.\nAnxiety\nDepression\nLoss of focus\nIrritability\nFatigue\nHyperactivity\nMood swings\nDizziness\nSleep disturbances\nChanges in heart rate\nChanges in blood pressure\nIn some cases, depression can be severe and lead to a condition called anhedonia, which is the inability to feel pleasure. This is usually temporary, but it can lead to suicidal thoughts or actions. If you start to experience extreme depression symptoms or suicidal thoughts, it\u2019s important to recognize that a severe chemical imbalance could cause it. Seeking professional help for addiction treatment can help."}],"name":"What Are The Ritalin Withdrawal Symptoms?"},"@type":"Question","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#QuestionsubjectOf_FAQPage_mainEntity1","acceptedAnswer":["@type":"Answer","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#QuestionsubjectOf_FAQPage_mainEntity1_acceptedAnswer_Answer","text":"\n72 hours: After your last dose of Ritalin, your first symptoms may show up within 72 hours. If you were used to a high dose for a long time, you might feel symptoms after 24 hours. Early symptoms may include sleep issues, anxiety, and irritability. You may also start to crave the drug.\n7 days: Symptoms will increase in intensity over the first week, and they will likely reach their peak within the first seven days. Peak symptoms are when the withdrawal period is at its most uncomfortable. Symptoms can include depression, insomnia, nausea, and fatigue.\n2 weeks: By the second week, your symptoms will start to subside. Psychological symptoms tend to linger longer than physical ones; you may continue to experience anxiety and depression. Cravings also last longer than other acute symptoms.\n1 month: In some cases, certain symptoms like anxiety may continue for a month or more. You may need to attend addiction treatment to address issues like drug cravings and psychological symptoms. Treatment can help you learn how to cope with ongoing issues without relapse.\n"],"name":"What Are The Stages Of The Ritalin Withdrawal Timeline?","@type":"Question","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#QuestionsubjectOf_FAQPage_mainEntity2","acceptedAnswer":["@type":"Answer","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#QuestionsubjectOf_FAQPage_mainEntity2_acceptedAnswer_Answer","text":"Ritalin isn\u2019t usually life-threatening during withdrawal like other drugs can be. Instead, it\u2019s more likely to cause uncomfortable physical and psychological symptoms.Detox is a high level of care in addiction treatment that\u2019s used to treat people that could go through severe withdrawal symptoms. However, it may also be used to treat people who have other health conditions that need to be addressed or monitored alongside withdrawal.For instance, stimulants like Ritalin can cause changes in heart rate and blood pressure that can be risky for people with heart conditions. Detox involves 24-hour medically managed services that usually lasts for about a week to 10 days, depending on your needs."],"name":"Why Should I Detox?","@type":"Question","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#QuestionsubjectOf_FAQPage_mainEntity3","acceptedAnswer":["@type":"Answer","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#QuestionsubjectOf_FAQPage_mainEntity3_acceptedAnswer_Answer","text":"Whether you complete detox, or if it\u2019s determined that you don\u2019t need it, you may still need additional levels of care in addiction treatment. NCBI of treatment, but it may not be all you need to treat addiction effectively.If you have significant medical or psychological needs that make living independently potentially dangerous, you may go through an inpatient or residential program. If you can live at home, you may go through an outpatient program. Through treatment, your plan will be personalized, and you\u2019ll meet regularly with a therapist. You may go through individual, family, and group therapy sessions depending on your plan."],"name":"What Is The Next Treatment Step?","@type":"Question","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#QuestionsubjectOf_FAQPage_mainEntity4","acceptedAnswer":["@type":"Answer","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#QuestionsubjectOf_FAQPage_mainEntity4_acceptedAnswer_Answer","text":"Ritalin withdrawal may not be as life-threatening as other drugs like central nervous system dependence. However, substance use disorders are chronic and progressive diseases. That means they may last a long time, and they will likely get worse over time, especially without the right treatment.Addiction is pervasive, and it can start to take over different aspects of your life as it progresses, including your health, relationships, and finances. Addiction treatment can help to address substance abuse problems and any underlying issues like mental health problems. To take a step toward recovery today, learn more about addiction and how it can be effectively treated."],"name":"Why Seek Treatment?"]}],"image":["@type":"ImageObject","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_image_ImageObject","url":"https:\/\/desertviewrecovery.com\/app\/uploads\/2019\/11\/Ritalin-Withdrawal-bgr.jpg"],"editor":["@type":"Person","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_editor_Person","name":"Elysia Richardson","url":"https:\/\/desertviewrecovery.com\/author\/erichardson\/","image":["@type":"ImageObject","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_editor_Person_image_ImageObject","url":"https:\/\/secure.gravatar.com\/avatar\/c5cfcddf8d9f8a1f96b8e51a4e3aa1bc?s=80&d=mm&r=g"]],"reviewedBy":["@type":"Person","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_reviewedBy_Person","image":["@type":"ImageObject","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_reviewedBy_Person_image_ImageObject","url":"https:\/\/desertviewrecovery.com\/app\/uploads\/2021\/05\/Loren-Miller-Square-150x150.jpg"],"url":"https:\/\/desertviewrecovery.com\/employee\/lmillerpbinstitute-com\/","name":"Loren Miller"],"publisher":["@type":"Organization","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_publisher_Organization","address":["@type":"PostalAddress","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_publisher_Organization_address_PostalAddress","postalCode":92270,"streetAddress":"70115 Highway 111","addressRegion":"CA ","addressLocality":"\nRancho Mirage"],"url":"https:\/\/desertviewrecovery.com\/","telephone":"+18885245912","logo":["@type":"ImageObject","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_publisher_Organization_logo_ImageObject","url":"https:\/\/desertviewrecovery.com\/app\/uploads\/2019\/12\/DV52pxH-01.svg"],"name":"Desert View Recovery"],"author":["@type":"Person","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_author_Person","url":"https:\/\/desertviewrecovery.com\/author\/joseph-raspolich\/","name":"https:\/\/desertviewrecovery.com\/author\/joseph-raspolich\/","description":" ","image":["@type":"ImageObject","@id":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#Article_MedicalWebPage_author_Person_image_ImageObject","url":"https:\/\/secure.gravatar.com\/avatar\/6faa1d54510ad2b23dddea8b3cec7c6b?s=80&d=mm&r=g"]],"about":"Ritalin Withdrawal","description":"Ritalin is a medication used to treat ADHD, but it can also cause dependence and uncomfortable withdrawal.","datePublished":"2022-01-19T18:53:15+00:00","headline":"Ritalin Withdrawal","mainEntityOfPage":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/"}"@context":"https:\/\/schema.org","@type":"BreadcrumbList","itemListElement":["@type":"ListItem","position":1,"name":"Detox Withdrawal: How It Works","item":"https:\/\/desertviewrecovery.com\/withdrawal\/#breadcrumbitem","@type":"ListItem","position":2,"name":"Ritalin Withdrawal","item":"https:\/\/desertviewrecovery.com\/withdrawal\/ritalin\/#breadcrumbitem"]window.schema_highlighter=accountId: "DelphiBehavioralHealthGroup/DesertView", output: false Skip to contentDesert View Recovery Addiction Treatment in Rancho Mirage
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